Non sedating h1 antihistamines
The observations indicate that non-sedating antihistamines, as opposed to what has been thought previously, may be helpful in patients with allergic rhinitis in whom nasal obstruction is a major concern.
Current international guidelines need to be revised in the light of the recent evidence.
Clinical studies sponsored by the manufacturer have shown that bilastine 20 mg once daily is as efficacious as other nonsedating antihistamines in allergic rhinoconjunctivitis and chronic urticaria in individuals from 12 and 18 years of age, respectively.
Bilastine is efficacious in all nasal symptoms including obstruction and in eye symptoms.
Cochrane: Me SH descriptor Common Cold explode all trees AND Me SH descriptor Histamine H1 Antagonists explode all trees 34 records 0 relevant.
Since these effects are not genuine antagonistic but rather represent a balance displacement between active and inactive forms of H1 receptors, now, the term H1 antihistamine rather than the former “antihistamine antagonist” is used .She is seeking care because she has a job interview in two days and wants to know if there is anything she can take to recover faster.You have heard that some providers use second generation antihistamines for upper respiratory infections, and wonder if there is any evidence behind the practice. Embase via the NHS Evidence Health Information Resources date of searching 04/04/11. [exp common-cold or exp respiratory-tract-infections/ or exp cough or exp nasal-obstruction or exp sneezing or exp rhinovirus] AND [exp cetirizine or exp loratadine or exp terfenadine or fexofenadine.mp].Research into aspects of pharmacokinetics and efficacy and adverse effect profiles of bilastine in children under 12 years of age is needed as are dose-response assessments and studies planned rigorously with the aim of assessing quality of life effects.Current guidelines for diagnosis and treatment of allergic rhinoconjunctivitis and urticaria recommend nonsedating antihistamines as first line treatment [1, 2].